Toasted Corn Flakes

Against biblical odds, the baseball version of a stage mom and her grifting ex road trip their kids’ baseball team across the midwest in the name of life, liberty, and the little league world series

Staging and engaging with media events: A study of the 2014 Eurovision Song Contest

Recent work on media events has questioned their integrative function, arguing that they operate as sites of symbolic struggle between different interest groups. However, relatively few studies have examined the experiences of those who design, organize, and attend such events. This article addresses this lacuna with reference to the biggest nonsporting live TV event in the world, the Eurovision Song Contest. Drawing on data from the 2014 competition in Copenhagen, Denmark, it examines the varying levels of commitment to the event among organizers, fans, broadcasters, and journalists and, in particular, notes how this shaped responses to a controversial incident involving the Russian entry. While those with an ongoing interest, including organizers and fans, tended to emphasize personal narratives and individual freedom of expression, mainstream media and audiences adopted a far more cynical standpoint, privileging geopolitical issues to make the event seem more relevant and compelling

Evolving from Planning and Scheduling to Real-Time Operations Support: Design Challenges

Versions of Scheduling and Planning Interface for Exploration (SPIFe) have supported a variety of mission operations across NASA. This software tool has evolved and matured over several years, assisting planners who develop intricate schedules. While initially conceived for surface Mars missions, SPIFe has been deployed in other domains, where people rather than robotic explorers, execute plans. As a result, a diverse set of end-users has compelled growth in a new direction: supporting real-time operations. This paper describes the new needs and challenges that accompany this development. Among the key features that have been built for SPIFe are current time indicators integrated into the interface and timeline, as well as other plan attributes that enable execution of scheduled activities. Field tests include mission support for the Lunar CRater Observation and Sensing Satellite (LCROSS), NASA Extreme Environment Mission Operations (NEEMO) and Desert Research and Technology Studies (DRATS) campaigns

The Heli-CASE of the Missing WRN Gene

Werner Syndrome is an autosomal recessive disease characterized by genomic instability, accelerated telomere shortening, and premature aging. Also, Werner Syndrome patients experience increased cancer rates, believed to be directly related to the lack of interaction between the WRN gene and tumor suppressor gene p53. The WRN gene consists of three identical molecules and has both exonuclease and helicase activity, which work together in opposite directions. WRN has been shown to stimulate polymerase â, needed in DNA repair. WRN helicase activity can also bind and degrade G-quadruplexes, which inhibit transcription. Studies show that the tumor suppressor gene p53 co-localizes with WRN during the S phase, inhibiting the exonuclease activity of WRN, and dulling WRN’s helicase ability to unwind Holliday Junctions; thus, revealing the regulation of WRN function by p53 is important for genomic stability. WRN also interacts with TRF2. TRF2 binds to DNA, attracts WRN, and stimulates the folding over of the 3’ overhang of telomeres. Absence of WRN leads to telomere loss and chromosomal fusion which lead to genome instability, accumulation of mutations, and thus cancer. The lack of WRN leads to premature senescence and exhibition of clinical symptoms of aging, even though 91% of RNA pol II transcription genes are expressed similarly to normal aging cells. The purpose of this review is to summarize current literature concerning the molecular pathways of Werner Syndrome

Software for Collaborative Use of Large Interactive Displays

The MERBoard Collaborative Workspace, which is currently being deployed to support the Mars Exploration Rover (MER) Missions, is the first instantiation of a new computing architecture designed to support collaborative and group computing using computing devices situated in NASA mission operations room. It is a software system for generation of large-screen interactive displays by multiple user

Ensemble: an Architecture for Mission-Operations Software

Ensemble is the name of an open architecture for, and a methodology for the development of, spacecraft mission operations software. Ensemble is also potentially applicable to the development of non-spacecraft mission-operations- type software. Ensemble capitalizes on the strengths of the open-source Eclipse software and its architecture to address several issues that have arisen repeatedly in the development of mission-operations software: Heretofore, mission-operations application programs have been developed in disparate programming environments and integrated during the final stages of development of missions. The programs have been poorly integrated, and it has been costly to develop, test, and deploy them. Users of each program have been forced to interact with several different graphical user interfaces (GUIs). Also, the strategy typically used in integrating the programs has yielded serial chains of operational software tools of such a nature that during use of a given tool, it has not been possible to gain access to the capabilities afforded by other tools. In contrast, the Ensemble approach offers a low-risk path towards tighter integration of mission-operations software tools

The Evaluation Of Az66, An Optimized Sigma Receptor Antagonist, Against Methamphetamine-Induced Dopaminergic Neurotoxicity And Memory Impairment In Mice

Sigma (σ) receptors have recently been identified as potential targets for the development of novel therapeutics aimed at mitigating the effects of methamphetamine. Particularly, σ receptors are believed to mitigate some of the neurotoxic effects of methamphetamine through modulation of dopamine, dopamine transporters and body temperature. Furthermore, recent evidence suggests that targeting σ receptors may prevent cognitive impairments produced by methamphetamine. In the present study, an optimized σ receptor antagonist, AZ66, was evaluated against methamphetamine-induced neurotoxicity and cognitive dysfunction. AZ66 was found to be highly selective for σ receptors compared to 64 other sites tested. Pretreatment of male, Swiss Webster mice with i.p. dosing of AZ66 significantly attenuated methamphetamine-induced striatal dopamine depletions, striatal dopamine transporter reductions and hyperthermia. Additionally, neurotoxic dosing with methamphetamine caused significant memory impairment in the object recognition test, which was attenuated when animals were pretreated with AZ66; similar trends were observed in the step-through passive avoidance test. Taken together, these results suggest that targeting σ receptors may provide neuroprotection against the neurotoxicity and cognitive impairments produced by methamphetamine

Staging and engaging with media events: A study of the 2014 Eurovision Song Contest

Recent work on media events has questioned their integrative function, arguing that they operate as sites of symbolic struggle between different interest groups. However, relatively few studies have examined the experiences of those who design, organize, and attend such events. This article addresses this lacuna with reference to the biggest nonsporting live TV event in the world, the Eurovision Song Contest. Drawing on data from the 2014 competition in Copenhagen, Denmark, it examines the varying levels of commitment to the event among organizers, fans, broadcasters, and journalists and, in particular, notes how this shaped responses to a controversial incident involving the Russian entry. While those with an ongoing interest, including organizers and fans, tended to emphasize personal narratives and individual freedom of expression, mainstream media and audiences adopted a far more cynical standpoint, privileging geopolitical issues to make the event seem more relevant and compelling